Available to mentor
Frederick Korley, M.D., Ph.D. is a Professor of Emergency Medicine at the University of Michigan. He completed his medical degree and residency training in emergency medicine at the Northwestern University where he served as chief resident. He subsequently completed a doctoral degree in clinical investigation at the Johns Hopkins University Bloomberg School of Public Health and was elected to Phi Beta Kappa. He was formerly on faculty at Johns Hopkins University as the inaugural recipient of Robert E. Meyerhoff Endowed Professorship.
His research work is focused on the development of novel diagnostics and therapeutics for traumatic brain injury (TBI). With regards to the development of novel diagnostics, Dr. Korley has two patents for biofluid-based biomarkers for brain injury detection and outcome prognostication. In collaboration with colleagues in engineering, Dr. Korley is developing a credit card-sized microfluidic device for point-of-care measurement of TBI biofluid biomarkers. He is also a national principal investigator of two federally funded multi-center research studies that are investigating the use of biofluid-based biomarkers for 1) subject selection in clinical trials; 2) monitoring individual patient response to promising neuroprotective agents. With regards to the development of therapeutics for TBI, Dr. Korley is a principal investigator of an NINDS funded phase II adaptive design clinical trial that is investigating the optimal treatment parameters of hyperbaric oxygen that is most likely to demonstrate improvement in the rate of good neurological outcome versus control in a subsequent confirmatory trial. During the ongoing COVID-19 pandemic, Dr. Korley is leveraging his expertise in the testing of novel therapeutics to lead an NHLBI-funded multi-center clinical trial of COVID-19 convalescent plasma in outpatients (C3PO) as one of the national co-PIs. He is a member of the NINDS Neurological Sciences and Disorders A (NSD-A) study section and the National Academies of Sciences, Engineering and Medicine’s Committee on Accelerating Progress in Traumatic Brain Injury Research and Care. Dr. Korley is the recipient of the 2021 Society of Academic Emergency Medicine (SAEM) Mid-Career Investigator Award.
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KL2 Clinical Research ScholarJohns Hopkins Institute for Clinical and Translational Research, Baltimore, 2012
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Emergency MedicineNorthwestern University Feinberg School of Medicine, Department of Emergency Medicine, 2007
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Emergency MedicineNorthwestern University Feinberg School of Medicine, Emergency Medicine, 2007
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Center MemberCenter for Integrative Research in Critical Care
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Center MemberUniversity of Michigan Injury Prevention Center
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Center MemberCenter for Computational Medicine and Bioinformatics
• Development of Novel Diagnostics and Therapeutics for Traumatic Brain Injury
• Building an Emergency Medicine Learning Health System
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Yue JK, Kanter JH, Barber JK, Huang MC, van Essen TA, Elguindy MM, Foreman B, Korley FK, Belton PJ, Pisică D, Lee YM, Kitagawa RS, Vassar MJ, Sun X, Satris GG, Wong JC, Ferguson AR, Huie JR, Wang KKW, Deng H, Wang VY, Bodien YG, Taylor SR, Madhok DY, McCrea MA, Ngwenya LB, DiGiorgio AM, Tarapore PE, Stein MB, Puccio AM, Giacino JT, Diaz-Arrastia R, Lingsma HF, Mukherjee P, Yuh EL, Robertson CS, Menon DK, Maas AIR, Markowitz AJ, Jain S, Okonkwo DO, Temkin NR, Manley GT, Chung JE, Coskun B, Eagle SR, Etemad LL, Fabian B, Ramana FV, Gopinath S, Gotthardt CJ, Grandhi R, Hamidi S, Jha RM, Madden C, Merchant R, Nelson LD, Rodgers RB, Schneider ALC, Schnyer DM, Torres-Espin A, Tracey JX, Valadka AB, Zafonte RD. The Lancet Regional Health - Americas, 2024 Nov 1; 39:Journal ArticleClinical profile of patients with acute traumatic brain injury undergoing cranial surgery in the United States: report from the 18-centre TRACK-TBI cohort study
DOI:10.1016/j.lana.2024.100915 -
Shi X, Wick JA, Martin RL, Beall J, Silbergleit R, Rockswold GL, Barsan WG, Korley FK, Rockswold S, Gajewski BJ. Stat Med, 2024 Aug 30; 43 (19): 3649 - 3663.Journal ArticleImproved mortality analysis in early-phase dose-ranging clinical trials for emergency medical diseases using Bayesian time-to-event models with active comparators.
DOI:10.1002/sim.10141 PMID: 38885949 -
Beal ML, Psoter KJ, Bechtold KT, Nagpaul V, Peters ME, Rao V, Van Meter TE, Falk H, Korley FK, Roy D. J Neuropsychiatry Clin Neurosci, 2024 Aug 8; appineuropsych20230143Journal ArticleRelationship Between Posttraumatic Headache and Depression After Mild Traumatic Brain Injury.
DOI:10.1176/appi.neuropsych.20230143 PMID: 39113495 -
Yue JK, Lee YM, Sun X, van Essen TA, Elguindy MM, Belton PJ, Pisică D, Mikolic A, Deng H, Kanter JH, McCrea MA, Bodien YG, Satris GG, Wong JC, Ambati VS, Grandhi R, Puccio AM, Mukherjee P, Valadka AB, Tarapore PE, Huang MC, DiGiorgio AM, Markowitz AJ, Yuh EL, Okonkwo DO, Steyerberg EW, Lingsma HF, Menon DK, Maas AIR, Jain S, Manley GT, The TRACK-TBI Investigators . J Neurosurg, 2024 Aug 1; 141 (2): 417 - 429.Journal ArticlePerformance of the IMPACT and CRASH prognostic models for traumatic brain injury in a contemporary multicenter cohort: a TRACK-TBI study.
DOI:10.3171/2023.11.JNS231425 PMID: 38489823 -
Yue JK, Etemad LL, Elguindy MM, van Essen TA, Belton PJ, Nelson LD, McCrea MA, Vreeburg RJG, Gotthardt CJ, Tracey JX, Coskun BC, Krishnan N, Halabi C, Eagle SR, Korley FK, Robertson CS, Duhaime A-C, Satris GG, Tarapore PE, Huang MC, Madhok DY, Giacino JT, Mukherjee P, Yuh EL, Valadka AB, Puccio AM, Okonkwo DO, Sun X, Jain S, Manley GT, DiGiorgio AM, TRACK-TBI Investigators , Badjatia N, Barber J, Bodien YG, Fabian B, Ferguson AR, Foreman B, Gardner RC, Gopinath S, Grandhi R, Russell Huie J, Dirk Keene C, Lingsma HF, MacDonald CL, Markowitz AJ, Merchant R, Ngwenya LB, Rodgers RB, Schneider ALC, Schnyer DM, Taylor SR, Temkin NR, Torres-Espin A, Vassar MJ, Wang KKW, Wong JC, Zafonte RD. Trauma Surg Acute Care Open, 2024 9 (1): e001501Journal ArticlePrior traumatic brain injury is a risk factor for in-hospital mortality in moderate to severe traumatic brain injury: a TRACK-TBI cohort study.
DOI:10.1136/tsaco-2024-001501 PMID: 39081460 -
Puccio AM, Yue JK, Korley FK, Okonkwo DO, Diaz-Arrastia R, Yuh EL, Ferguson AR, Mukherjee P, Wang KKW, Taylor SR, Deng H, Markowitz AJ, Sun X, Jain S, Manley GT. J Neurotrauma, 2024 Jun; 41 (11-12): 1353 - 1363.Journal ArticleDiagnostic Utility of Glial Fibrillary Acidic Protein Beyond 12 Hours After Traumatic Brain Injury: A TRACK-TBI Study.
DOI:10.1089/neu.2023.0186 PMID: 38251868 -
Yue JK, Yuh EL, Elguindy MM, Sun X, van Essen TA, Deng H, Belton PJ, Satris GG, Wong JC, Valadka AB, Korley FK, Robertson CS, McCrea MA, Stein MB, Diaz-Arrastia R, Wang KKW, Temkin NR, DiGiorgio AM, Tarapore PE, Huang MC, Markowitz AJ, Puccio AM, Mukherjee P, Okonkwo DO, Jain S, Manley GT. J Neurotrauma, 2024 Jun; 41 (11-12): 1310 - 1322.Journal ArticleIsolated Traumatic Subarachnoid Hemorrhage on Head Computed Tomography Scan May Not Be Isolated: A Transforming Research and Clinical Knowledge in Traumatic Brain Injury Study (TRACK-TBI) Study.
DOI:10.1089/neu.2023.0253 PMID: 38450561 -
Mamer LE, Cranford JA, Kocher KE, Korley FK, Scott PA. Journal of Clinical and Translational Science, 2024 Apr 3; 8 (s1): 98 - 98.Proceeding / Abstract / PosterEmergency Department Use of Neuroimaging and Hospitalization for Transient Ischemic Attacks in the United States: A Cross-Sectional Study
DOI:10.1017/cts.2024.290
