Available to mentor
Dr. Paulson is the Lucile Groff Professor of Neurology in the Department of Neurology at the University of Michigan, where he also serves as Director of the Michigan Alzheimer’s Disease Center. Dr. Paulson received his MD and PhD degrees from Yale University, completed residency and fellowship training at the University of Pennsylvania, and previously taught at the University of Iowa. His research and clinical interests concern the causes and treatment of age-related neurodegenerative diseases, with an emphasis on repeat expansion diseases and age-related dementias. He is a member of the National Academy of Medicine, an elected fellow of the American Association for the Advancement of Science, and a recipient of the Landis Outstanding Mentor Award from the National Institutes of Health.
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movement disorders and neurogeneticsUniversity of Pennsylvania Health System, Philadelphia, 1997
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Center MemberTaubman Institute
Dr. Paulson's basic and clinical research focuses on age-related neurodegenerative diseases including Alzheimer's and related dementias as well as hereditary movement disorders including the ataxias. He directs the Michigan Alzheimer's Disease Center, which supports a wide range research projects to understand the causes and treatment of cognitive impairment. His laboratory studies the molecular mechanisms of various neurodegenerative diseases, with the goal of identifying therapeutic targets that can lead to treatments for currently fatal disorders.
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Petit E, Schmitz-Hübsch T, Coarelli G, Jacobi H, Heinzmann A, Figueroa KP, Perlman SL, Gomez CM, Wilmot GR, Schmahmann JD, Ying SH, Zesiewicz TA, Paulson HL, Shakkottai VG, Bushara KO, Kuo S-H, Geschwind MD, Xia G, Pulst SM, Subramony SH, Ewenczyk C, Brice A, Durr A, Klockgether T, Ashizawa T, Tezenas du Montcel S. J Neurol, 2024 Jul; 271 (7): 3743 - 3753.Journal ArticleSARA captures disparate progression and responsiveness in spinocerebellar ataxias.
DOI:10.1007/s00415-024-12475-1 PMID: 38822840 -
Armstrong MJ, Dai Y, Sovich K, LaBarre B, Paulson HL, Maixner SM, Fields JA, Lunde AM, Forsberg LK, Boeve BF, Manning CA, Galvin JE, Taylor AS, Li Z. Neurol Clin Pract, 2024 Jun; 14 (3): e200292Journal ArticleCaregiver Experiences and Burden in Moderate-Advanced Dementia With Lewy Bodies.
DOI:10.1212/CPJ.0000000000200292 PMID: 38617555 -
Uebachs M, Wegner P, Schaaf S, Kugai S, Jacobi H, Kuo S-H, Ashizawa T, Fluck J, EUROSCA study group , ESMI study group , RISCA study group , CRC-SCA study group , SCA Registry study group , Klockgether T, Faber J. Cerebellum, 2024 Jun; 23 (3): 887 - 895.Journal ArticleSCAview: an Intuitive Visual Approach to the Integrative Analysis of Clinical Data in Spinocerebellar Ataxias.
DOI:10.1007/s12311-023-01546-0 PMID: 37002505 -
Lai R-Y, Rummey C, Amlang CJ, Lin C-YR, Chen TX, Perlman S, Wilmot G, Gomez CM, Schmahmann JD, Paulson H, Ying SH, Onyike CU, Zesiewicz TA, Bushara KO, Geschwind MD, Figueroa KP, Pulst SM, Subramony SH, Burns MR, Opal P, Duquette A, Ashizawa T, Hamedani AG, Davis MY, Srinivasan SR, Moore LR, Shakkottai VG, Rosenthal LS, Kuo S-H. Mov Disord Clin Pract, 2024 May; 11 (5): 496 - 503.Journal ArticleFatigue Impacts Quality of Life in People with Spinocerebellar Ataxias.
DOI:10.1002/mdc3.14006 PMID: 38419568 -
Albertson R, Paulson H, Srinivasan S, Shakkottai V, Todd P. Neurology, 2024 Apr 9; 102 (17_supplement_1):Journal ArticleDiagnostic Yield of Genetic Testing Over Five Years in a Tertiary Ataxia Clinic (P7-3.017)
DOI:10.1212/wnl.0000000000205545 -
Armstrong MJ, LaBarre B, Sovich K, Maixner SM, Paulson HL, Manning C, Fields JA, Lunde A, Forsberg L, Boeve BF, Galvin JE, Taylor AS, Li Z. Alzheimers Dement, 2024 Apr; 20 (4): 2719 - 2730.Journal ArticlePatient- and proxy-reported quality of life in advanced dementia with Lewy bodies.
DOI:10.1002/alz.13745 PMID: 38400528 -
Xicota L, Cosentino S, Vardarajan B, Mayeux R, Perls TT, Andersen SL, Zmuda JM, Thyagarajan B, Yashin A, Wojczynski MK, Krinsky-McHale S, Handen BL, Christian BT, Head E, Mapstone ME, Schupf N, Lee JH, Barral S, Long‐Life Family Study (LLFS) , Alzheimer's Disease Genetic Consortium (ADGC) , Alzheimer's Biomarkers Consortium‐Down Syndrome (ABC‐DS) . Alzheimers Dement, 2024 Apr; 20 (4): 2670 - 2679.Journal ArticleWhole genome-wide sequence analysis of long-lived families (Long-Life Family Study) identifies MTUS2 gene associated with late-onset Alzheimer's disease.
DOI:10.1002/alz.13718 PMID: 38380866 -
Safren N, Dao TP, Mohan HM, Huang C, Trotter B, Castañeda CA, Paulson H, Barmada S, Sharkey LM. Sci Rep, 2024 Mar 13; 14 (1): 6049Journal ArticlePathogenic mutations in UBQLN2 exhibit diverse aggregation propensity and neurotoxicity.
DOI:10.1038/s41598-024-55582-9 PMID: 38472280