Brehm Tower 5128, Kellogg Eye Center, 1000 Wall St.
Ann Arbor, MI 48105
Available to mentor
Dr. Les Satin is the Joanne I. Moore Endowed Research Professor of Pharmacology and also an investigator in the Brehm Diabetes Research Center and the Caswell Diabetes Institute. He is an affiliate professor of MEND, in Internal Medicine. He trained at UCLA, SUNY Stony Brook, and the University of Washington, Seattle, where he was in the Department of Physiology and Biophysics of the UW Medical School and a fellow in Metabolism and Endocrinology at the Seattle Veterans Affairs Medical Center. Dr. Satin was trained in the areas of membrane biophysics, neurobiology, electrophysiology and ion channels. He has been on the faculty at UM since 2008. In 2016, Dr. Satin was visiting professor at the University of Uppsala in Uppsala, Sweden with Drs. Anders Tengholm and Sebastian Barg in the Department of Medical Cell Biology.
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fellowUniversity of Washington, Seattle, Physiology and Biophysics, 1990
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postdoctoral fellowSUNY Stont Brook, Neurobiology and Behavior, 1984
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Ph.D.University of California at Los Angeles, Los Angeles, 1982
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Center MemberCaswell Diabetes Institute
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Center MemberCenter for Integrative Research in Critical Care
Pancreatic islets, beta cell stimulus secretion coupling, beta cell biology, oscillations in biological systems, calcium signaling in organelles and cytosol, mathematical modeling, genetically encoded sensors, live cell imaging.
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Satin LS, Corradi J, Sherman AS. Diabetes, 2024 Jun 1; 73 (6): 844 - 848.Journal ArticleDo We Need a New Hypothesis for KATP Closure in β-Cells? Distinguishing the Baby From the Bathwater.
DOI:10.2337/db24-0131 PMID: 38640066 -
Arunagiri A, Alam M, Haataja L, Draz H, Alasad B, Samy P, Sadique N, Tong Y, Cai Y, Shakeri H, Fantuzzi F, Ibrahim H, Jang I, Sidarala V, Soleimanpour SA, Satin LS, Otonkoski T, Cnop M, Itkin-Ansari P, Kaufman RJ, Liu M, Arvan P. Protein Sci, 2024 Apr; 33 (4): e4949Journal ArticleProinsulin folding and trafficking defects trigger a common pathological disturbance of endoplasmic reticulum homeostasis.
DOI:10.1002/pro.4949 PMID: 38511500 -
Corradi J, Thompson B, Fletcher PA, Bertram R, Sherman AS, Satin LS. J Physiol, 2023 Dec; 601 (24): 5655 - 5667.Journal ArticleKATP channel activity and slow oscillations in pancreatic beta cells are regulated by mitochondrial ATP production.
DOI:10.1113/JP284982 PMID: 37983196 -
Bertram R, Marinelli I, Fletcher PA, Satin LS, Sherman AS. Math Biosci, 2023 Nov; 365: 109085Journal ArticleDeconstructing the integrated oscillator model for pancreatic β-cells.
DOI:10.1016/j.mbs.2023.109085 PMID: 37802364 -
Jo S, Beetch M, Gustafson E, Wong A, Oribamise E, Chung G, Vadrevu S, Satin LS, Bernal-Mizrachi E, Alejandro EU. J Endocr Soc, 2023 Aug 2; 7 (9): bvad099Journal ArticleSex Differences in Pancreatic β-Cell Physiology and Glucose Homeostasis in C57BL/6J Mice.
DOI:10.1210/jendso/bvad099 PMID: 37873500 -
Zhang IX, Herrmann A, Leon J, Jeyarajan S, Arunagiri A, Arvan P, Gilon P, Satin LS. J Biol Chem, 2023 Aug; 299 (8): 105065Journal ArticleER stress increases expression of intracellular calcium channel RyR1 to modify Ca2+ homeostasis in pancreatic beta cells.
DOI:10.1016/j.jbc.2023.105065 PMID: 37468098 -
Fletcher PA, Thompson B, Liu C, Bertram R, Satin LS, Sherman AS. Am J Physiol Endocrinol Metab, 2023 Jun 1; 324 (6): E477 - E487.Journal ArticleCa2+ release or Ca2+ entry, that is the question: what governs Ca2+ oscillations in pancreatic β cells?
DOI:10.1152/ajpendo.00030.2023 PMID: 37074988 -
Satin L. Calcium Signals, 1-1-1-3ChapterIntroduction
DOI:10.1088/978-0-7503-2009-2ch1
