Matthias Kretzler, MD
Warner-Lambert/Parke-Davis Professor of Medicine
Professor of Internal Medicine and Research Professor
Computational Medicine and Bioinformatics
[email protected]

Available to mentor
Matthias Kretzler, MD
Professor
  • Qualifications
  • Center Memberships
  • Research Overview
  • Links
  • Recent Publications
    • Qualifications
    • PhD
      University of Heidelberg, Heidelberg, 1993
    • MD
      University of Heidelberg, Heidelberg, 1992
    • Baccalaureate
      St. Paulusheim, Bruchsal, 1985
    Center Memberships
    • Center Member
      Biosciences Initiative
    • Center Member
      Global REACH
    • Center Member
      Precision Health Initiative
    • Center Member
      MM-PKUHSC Joint Institute
    • Center Member
      Center for Computational Medicine and Bioinformatics
    • Center Member
      Caswell Diabetes Institute
    Research Overview

    Defining the molecular pathophysiology of glomerular disease for function-based disease management in international, multidisciplinary research networks

    Integrative systems biology of renal disease with a focus on glomerular diseases

    Molecular diagnostic and target identification of renal disease

    Links
    • MiKTMC
    Recent Publications See All Publications
    • Journal Article
      Lupus-prone NZM2328 mice exhibit enhanced UV-induced myeloid cell recruitment and activation in a type I interferon dependent manner.
      Maz MP, Reddy AL, Berthier CC, Tsoi LC, Colesa DJ, Wolf SJ, Shi H, Loftus SN, Moallemian R, Bogle R, Kretzler M, Jacob CO, Gudjonsson JE, Kahlenberg JM. J Autoimmun, 2024 Sep 5; 149: 103296 DOI:10.1016/j.jaut.2024.103296
      PMID: 39241536
    • Journal Article
      WNT-dependent interaction between inflammatory fibroblasts and FOLR2+ macrophages promotes fibrosis in chronic kidney disease.
      Cohen C, Mhaidly R, Croizer H, Kieffer Y, Leclere R, Vincent-Salomon A, Robley C, Anglicheau D, Rabant M, Sannier A, Timsit M-O, Eddy S, Kretzler M, Ju W, Mechta-Grigoriou F. Nat Commun, 2024 Jan 25; 15 (1): 743 DOI:10.1038/s41467-024-44886-z
      PMID: 38272907
    • Journal Article
      Perioperative Acute Kidney Injury: Diagnosis, Prediction, Prevention, and Treatment.
      Douville NJ, Mathis M, Kheterpal S, Heung M, Schaub J, Naik A, Kretzler M. Anesthesiology, 2024 Nov 11; DOI:10.1097/ALN.0000000000005215
      PMID: 39527650
    • Journal Article
      Association of urinary EGF, FABP3, and VCAM1 levels with the progression of early diabetic kidney disease
      Keller F, Denicolò S, Leierer J, Kruus M, Heinzel A, Kammer M, Ju W, Nair V, Burdet F, Ibberson M, Menon R, Otto E, Choi YJ, Pyle L, Ladd P, Bjornstad PM, Eder S, Rosivall L, Mark PB, Wiecek A, Heerspink HJL, Kretzler M, Oberbauer R, Mayer G, Perco P. Kidney & Blood Pressure Research, 1 - 21. DOI:10.1159/000542267
    • Journal Article
      Association of Autoantibody Concentrations and Trajectories With Lupus Nephritis Histologic Features and Treatment Response.
      Fava A, Wagner CA, Guthridge CJ, Kheir J, Macwana S, DeJager W, Gross T, Izmirly P, Belmont HM, Diamond B, Davidson A, Utz PJ, Weisman MH, Magder LS, Accelerating Medicines Partnership Rheumatoid Arthritis and Systemic Lupus Erythematosus (AMP RA/SLE) Network , Guthridge JM, Petri M, Buyon J, James JA. Arthritis Rheumatol, 2024 Nov; 76 (11): 1611 - 1622. DOI:10.1002/art.42941
      PMID: 38962936
    • Journal Article
      Attenuated kidney oxidative metabolism in young adults with type 1 diabetes.
      Choi YJ, Richard G, Zhang G, Hodgin JB, Demeke DS, Yang Y, Schaub JA, Tamayo IM, Gurung BK, Naik AS, Nair V, Birznieks C, MacDonald A, Narongkiatikhun P, Gross S, Driscoll L, Flynn M, Tommerdahl K, Nadeau KJ, Shah VN, Vigers T, Snell-Bergeon JK, Kendrick J, van Raalte DH, Li L-P, Prasad P, Ladd P, Chin BB, Cherney DZ, McCown PJ, Alakwaa F, Otto EA, Brosius FC, Saulnier PJ, Puelles VG, Goodrich JA, Street K, Venkatachalam MA, Ruiz A, de Boer IH, Nelson RG, Pyle L, Blondin DP, Sharma K, Kretzler M, Bjornstad P. J Clin Invest, 2024 Oct 22; DOI:10.1172/JCI183984
      PMID: 39436695
    • Journal Article
      AKI in the Kidney Precision Medicine Project: Acute Tubular Injury vs. Acute Interstitial Nephritis
      Schaub JA, Castro AMV, Menez S, Wen Y, Menon R, Bhatraju PK, Wilson FP, Coca SG, Eadon MT, Bomback AS, Moledina DG, Cantley LG, Palevsky PM, D'Agati VD, Randhawa PS, Murugan R, Alpers CE, Kretzler M, Himmelfarb J, Parikh CR. Journal of the American Society of Nephrology, 2024 Oct; 35 (10S): 10.1681/asn.2024cxh8wvky DOI:10.1681/asn.2024cxh8wvky
    • Journal Article
      An Omnibus of Transcripts Integrated from More than One Million Nuclei and Cells of Patients with Kidney Diseases Provides Distinct Insights into Disease Mechanisms
      McCown PJ, Otto EA, Fermin D, Hartman JR, Alaba MO, Larkina M, Arbit M, Helmuth M, Godfrey BA, Eddy S, Mariani LH, Naik AS, Hoek M, Satterfield T, Kretzler M. Journal of the American Society of Nephrology, 2024 Oct; 35 (10S): 10.1681/asn.2024thq273wq DOI:10.1681/asn.2024thq273wq