Yuqing E Chen
Frederick G L Huetwell Professor of Cardiovascular Medicine
Professor of Internal Medicine
Professor of Surgery
Professor of Pharmacology
Professor of Molecular and Integrative Physiology
[email protected]

Available to mentor
Yuqing E Chen
Professor
  • About
  • Center Memberships
  • Recent Publications
    • About

    Dr. Chen is an expert in diabetes and cardiovascular disease. He cloned Exendin 4 (BYETTA), facilitating GLP1 drug development. He discovered the mechanisms of nitro-fatty acids, novel anti-inflammatory signaling molecules, currently in phase 2 clinical trials. Recently he embarked in successful integration of human genetic discoveries with translational research.

    Center Memberships
    • Center Member
      MM-PKUHSC Joint Institute
    • Center Member
      Center for Integrative Research in Critical Care
    • Center Member
      Samuel and Jean Frankel Cardiovascular Center
    • Center Member
      Caswell Diabetes Institute
    • Center Member
      Biosciences Initiative
    Recent Publications See All Publications
    • Journal Article
      XBP1-mediated transcriptional regulation of SLC5A1 in human epithelial cells in disease conditions.
      Sun Y, Zhang Y, Zhang J, Chen YE, Jin J-P, Zhang K, Mou H, Liang X, Xu J. Cell Biosci, 2024 Feb 22; 14 (1): 27 DOI:10.1186/s13578-024-01203-x
      PMID: 38388523
    • Journal Article
      Bioengineered vascular grafts with a pathogenic TGFBR1 variant model aneurysm formation in vivo and reveal underlying collagen defects.
      Yang Y, Feng H, Tang Y, Wang Z, Qiu P, Huang X, Chang L, Zhang J, Chen YE, Mizrak D, Yang B. Sci Transl Med, 2024 May 8; 16 (746): eadg6298 DOI:10.1126/scitranslmed.adg6298
      PMID: 38718134
    • Journal Article
      Hepatic danger signaling triggers TREM2+ macrophage induction and drives steatohepatitis via MS4A7-dependent inflammasome activation.
      Zhou L, Qiu X, Meng Z, Liu T, Chen Z, Zhang P, Kuang H, Pan T, Lu Y, Qi L, Olson DP, Xu XZS, Chen YE, Li S, Lin JD. Sci Transl Med, 2024 Mar 13; 16 (738): eadk1866 DOI:10.1126/scitranslmed.adk1866
      PMID: 38478630
    • Journal Article
      Serine synthesis via reversed SHMT2 activity drives glycine depletion and acetaminophen hepatotoxicity in MASLD.
      Ghrayeb A, Finney AC, Agranovich B, Peled D, Anand SK, McKinney MP, Sarji M, Yang D, Weissman N, Drucker S, Fernandes SI, Fernández-García J, Mahan K, Abassi Z, Tan L, Lorenzi PL, Traylor J, Zhang J, Abramovich I, Chen YE, Rom O, Mor I, Gottlieb E. Cell Metab, 2024 Jan 2; 36 (1): 116 - 129.e7. DOI:10.1016/j.cmet.2023.12.013
      PMID: 38171331
    • Journal Article
      International Accolades for GLP-1 Research: Recognizing Pioneers in Diabetes and Obesity Treatment Across Five Prestigious Awards.
      Jin T, Chen YE. Cardiovasc Drugs Ther, 2024 Oct 29; DOI:10.1007/s10557-024-07630-9
      PMID: 39470894
    • Journal Article
      SWI/SNF Complex in Vascular Smooth Muscle Cells and Its Implications in Cardiovascular Pathologies.
      Liu H, Zhao Y, Zhao G, Deng Y, Chen YE, Zhang J. Cells, 2024 Jan 16; 13 (2): DOI:10.3390/cells13020168
      PMID: 38247859
    • Journal Article
      Sotagliflozin attenuates liver-associated disorders in cystic fibrosis rabbits.
      Liang X, Hou X, Bouhamdan M, Sun Y, Song Z, Rajagopalan C, Jiang H, Wei H-G, Song J, Yang D, Guo Y, Zhang Y, Mou H, Zhang J, Chen YE, Sun F, Jin J-P, Zhang K, Xu J. JCI Insight, 2024 Feb 15; 9 (6): DOI:10.1172/jci.insight.165826
      PMID: 38358827
    • Preprint
      Transient BRD4 degradation improves cardiac reprogramming by inhibiting macrophage/Oncostatin M induced JAK/STAT pathway
      Liu L, Guo Y, Tian S, Lei I, Gao W, Li Z, Wang S, Chen YE, Wang Z. bioRxiv, DOI:10.1101/2023.12.31.573781