Available to mentor
Dr. Olson is a physician scientist with clinical training in pediatrics and pediatric endocrinology. He leads a research laboratory focused on dissecting the neural mechanisms of energy balance control and metabolism. He is Co-director of the T32 training grant in Pediatric Endocrinology and is the Director of the Michigan Diabetes Research Center's Molecular Genetics Core. Dr. Olson also serves as the Associate Chair for Research in Pediatrics.
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FellowBoston Children's Hospital, Pediatrics, 2005
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ResidentBoston Children's Hospital, Pediatrics, 2002
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Center MemberCaswell Diabetes Institute
The Olson lab is committed to determining the mechanisms by which the brain regulates feeding, energy expenditure, body weight and glucose metabolism. Our research uses advanced molecular genetic techniques to manipulate discrete subsets of neurons in the hypothalamus and hindbrain. Using rodent models, we aim to determine the role that specific neurons play in energy homeostasis, feeding behavior and peripheral glucose handling.
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Li Y, Kim M-H, Jiang L, Baron L, Faulkner LD, Olson DP, Li X, Gannot N, Li P, Rui L. Adv Sci (Weinh), 2024 Aug; 11 (31): e2400437Journal ArticleSH2B1 Defends Against Energy Imbalance, Obesity, and Metabolic Disease via a Paraventricular Hypothalamus→Dorsal Raphe Nucleus Neurocircuit.
DOI:10.1002/advs.202400437 PMID: 38885417 -
Zhou L, Qiu X, Meng Z, Liu T, Chen Z, Zhang P, Kuang H, Pan T, Lu Y, Qi L, Olson DP, Xu XZS, Chen YE, Li S, Lin JD. Sci Transl Med, 2024 Mar 13; 16 (738): eadk1866Journal ArticleHepatic danger signaling triggers TREM2+ macrophage induction and drives steatohepatitis via MS4A7-dependent inflammasome activation.
DOI:10.1126/scitranslmed.adk1866 PMID: 38478630 -
Moore DJ, Powell W, Boyer D, Bline K, Harshman L, Nowalk A, Burns A, Orange JS, NPSCW . Pediatr Res, 2024 Jan; 95 (1): 70 - 74.Journal ArticleNational Pediatrician-Scientist Collaborative Workgroup comment on new ACGME requirements' impact on pediatric physician-scientists.
DOI:10.1038/s41390-023-02795-9 PMID: 37684431 -
Rupp AC, Tomlinson AJ, Affinati AH, Yacawych WT, Duensing AM, True C, Lindsley SR, Kirigiti MA, MacKenzie A, Polex-Wolf J, Li C, Knudsen LB, Seeley RJ, Olson DP, Kievit P, Myers MG. J Clin Invest, 2023 Oct 2; 133 (19):Journal ArticleSuppression of food intake by Glp1r/Lepr-coexpressing neurons prevents obesity in mouse models.
DOI:10.1172/JCI157515 PMID: 37581939 -
Olson D. 2023 Mar 13;PresentationCentral Glp1R signaling and energy balance
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Affinati AH, Elias CF, Olson DP, Myers MG. 2023 Metabolic Syndrome, 283 - 301.ChapterBrain Regulation of Feeding and Energy Homeostasis
DOI:10.1007/978-3-031-40116-9_22 -
FAULKNER LD, LEWIS K, MEEK TH, MERCER AJ, MACDOUGALD OA, OLSON D. Diabetes, 2022 Jun 1; 71 (Supplement_1):Proceeding / Abstract / Poster210-LB: Central Regulation of Peripheral Adiposity by Nos1PVHNeurons
DOI:10.2337/db22-210-lb -
2022 Jun 1;PresentationRole of the VMN in glucose disposal