David S Lorberbaum
Assistant Professor of Pharmacology
Department of Pharmacology
1000 Wall Street
Ann Arbor, MI 48105
[email protected]

Available to mentor
David S Lorberbaum
Assistant Professor
  • About
  • Links
  • Qualifications
  • Center Memberships
  • Research Overview
  • Recent Publications
    • About

    The pancreas is a multifunctional organ and is susceptible to a myriad of diseases. We use a combination of in vivo mouse genetics, in vitro human-derived embryonic stem cell differentiations, and ex vivo pancreatic organoid cultures to define the mechanisms by which the pancreas develops, matures, and functions in health and disease with the ultimate goal of improving therapeutic treatments for pancreas disorders, like diabetes and agenesis.

    Links
    • Laboratory Website
    Qualifications
    • Postdoctoral Fellow
      University of Colorado Denver Anschutz Medical Campus, Barbara Davis Center for Diabetes, 2023
    • PhD
      University of Michigan, Ann Arbor, 2016
    Center Memberships
    • Center Member
      Caswell Diabetes Institute
    • Center Member
      Center for Cell Plasticity and Organ Design
    Research Overview

    Cell signaling, gene regulation, transcription factors, context-specific gene expression, development, cell biology, diabetes, pancreas agenesis, stem cell derived islets, organoids, mouse genetics, disease models

    Recent Publications See All Publications
    • Preprint
      Meningeal-derived retinoic acid regulates neurogenesis via suppression of Notch and Sox2
      Como CN, O’Rourke R, Winkler C, Mitchell D, Tran L, Lorberbaum D, Sussel L, Franco S, Siegenthaler J. bioRxiv, DOI:10.1101/2024.04.05.588348
    • Journal Article
      Leveraging the strengths of mice, human stem cells, and organoids to model pancreas development and diabetes.
      Lorberbaum DS, Sarbaugh D, Sussel L. Front Endocrinol (Lausanne), 2022 13: 1042611 DOI:10.3389/fendo.2022.1042611
      PMID: 36339450
    • Journal Article
      Modeling Hypoxia-Induced Neuropathies Using a Fast and Scalable Human Motor Neuron Differentiation System.
      Hudish LI, Bubak A, Triolo TM, Niemeyer CS, Lorberbaum DS, Sussel L, Nagel M, Taliaferro JM, Russ HA. Stem Cell Reports, 2021 Apr 13; 16 (4): 1009 DOI:10.1016/j.stemcr.2021.03.006
      PMID: 33852882
    • Journal Article
      Contrast-enhanced ultrasound with sub-micron sized contrast agents detects insulitis in mouse models of type1 diabetes.
      Ramirez DG, Abenojar E, Hernandez C, Lorberbaum DS, Papazian LA, Passman S, Pham V, Exner AA, Benninger RKP. Nat Commun, 2020 May 7; 11 (1): 2238 DOI:10.1038/s41467-020-15957-8
      PMID: 32382089
    • Journal Article
      Retinoic acid signaling within pancreatic endocrine progenitors regulates mouse and human β cell specification.
      Lorberbaum DS, Kishore S, Rosselot C, Sarbaugh D, Brooks EP, Aragon E, Xuan S, Simon O, Ghosh D, Mendelsohn C, Gadue P, Sussel L. Development, 2020 Jun 22; 147 (12): DOI:10.1242/dev.189977
      PMID: 32467243
    • Journal Article
      Modeling Hypoxia-Induced Neuropathies Using a Fast and Scalable Human Motor Neuron Differentiation System.
      Hudish LI, Bubak A, Triolo TM, Niemeyer CS, Lorberbaum DS, Sussel L, Nagel M, Taliaferro JM, Russ HA. Stem Cell Reports, 2020 Jun 9; 14 (6): 1033 - 1043. DOI:10.1016/j.stemcr.2020.04.003
      PMID: 32386561
    • Journal Article
      2046-P: Retinoic Acid Signaling in Pancreatic Endocrine Cells Regulates Islet Cell Specification
      LORBERBAUM D, SUSSEL L. Diabetes, 2020 Jun 1; 69 (Supplement_1): DOI:10.2337/db20-2046-p
    • Journal Article
      Pancreatic β cell regeneration: To β or not to β.
      Guney MA, Lorberbaum DS, Sussel L. Curr Opin Physiol, 2020 Apr; 14: 13 - 20. DOI:10.1016/j.cophys.2019.10.019
      PMID: 32864533