Uhn-Soo Cho, PhD
Associate Professor of Biological Chemistry
Department of Biological Chemistry
1150 W. Medical Center Dr., 4220E MSRB III
Ann Arbor, MI 48109
[email protected]

Available to mentor
Uhn-Soo Cho, PhD
Associate Professor
  • Qualifications
  • Research Overview
  • Links
  • Recent Publications
    • Qualifications
    • HHMI Postdoctoral Fellow
      Harvard Medical School, Boston, 2012
    • PhD
      University of Washington, Seattle, 2007
    • MS
      Korea University, Seoul, 2000
    • BS
      Korea University, Seoul, 1998
    Research Overview

    Our laboratory is interested in illustrating the molecular mechanisms of key biological events, particularly epigenetic regulation and metabolic homeostasis, using structural biology as major tools. We use X-ray crystallography and cryogenic electron microscopy to determine the atomic level of macromolecular structures to understand its mechanisms.

    Links
    • The Cho laboratory
    Recent Publications See All Publications
    • Journal Article
      Structural basis for Mis18 complex assembly and its implications for centromere maintenance.
      Thamkachy R, Medina-Pritchard B, Park SH, Chiodi CG, Zou J, de la Torre-Barranco M, Shimanaka K, Abad MA, Gallego Páramo C, Feederle R, Ruksenaite E, Heun P, Davies OR, Rappsilber J, Schneidman-Duhovny D, Cho U-S, Jeyaprakash AA. EMBO Rep, 2024 Aug; 25 (8): 3348 - 3372. DOI:10.1038/s44319-024-00183-w
      PMID: 38951710
    • Book
      The Core Complex of Yeast COMPASS and Human Mixed-Lineage Leukemia (MLL), Structure, Function, and Recognition of the Nucleosome
      Cho U-S. 2024 Jul 5; DOI:10.1007/978-3-031-58843-3_6
    • Journal Article
      The Core Complex of Yeast COMPASS and Human Mixed-Lineage Leukemia (MLL), Structure, Function, and Recognition of the Nucleosome.
      Cho U-S. Subcell Biochem, 2024 104: 101 - 117. DOI:10.1007/978-3-031-58843-3_6
      PMID: 38963485
    • Journal Article
      Non-canonical MLL1 activity regulates centromeric phase separation and genome stability.
      Sha L, Yang Z, An S, Yang W, Kim S, Oh H, Xu J, Yin J, Wang H, Lenz H-J, An W, Cho U-S, Dou Y. Nat Cell Biol, 2023 Nov; 25 (11): 1637 - 1649. DOI:10.1038/s41556-023-01270-1
      PMID: 37945831
    • Journal Article
      Batch Production of High-Quality Graphene Grids for Cryo-EM: Cryo-EM Structure of Methylococcus capsulatus Soluble Methane Monooxygenase Hydroxylase.
      Ahn E, Kim B, Park S, Erwin AL, Sung SH, Hovden R, Mosalaganti S, Cho U-S. ACS Nano, 2023 Mar 28; 17 (6): 6011 - 6022. DOI:10.1021/acsnano.3c00463
      PMID: 36926824
    • Journal Article
      Iditarod, a Drosophila homolog of the Irisin precursor FNDC5, is critical for exercise performance and cardiac autophagy.
      Cobb T, Hwang I, Soukar M, Namkoong S, Cho U-S, Safdar M, Kim M, Wessells RJ, Lee JH. Proc Natl Acad Sci U S A, 2023 Sep 26; 120 (39): e2220556120 DOI:10.1073/pnas.2220556120
      PMID: 37722048
    • Journal Article
      Development of an atmospheric plasma jet device for versatile treatment of electron microscope sample grids.
      Ahn E, Tang T, Kim B, Lee HJ, Cho U-S. J Biol Chem, 2022 Apr; 298 (4): 101793 DOI:10.1016/j.jbc.2022.101793
      PMID: 35248533
    • Patent
      GRAPHENE SUPPORTED CRYO-ELECTRON MICROSCOPY GRID
    Featured News & Stories
    Department News
    Cho lab publishes research article in ACS Nano
    The Cho lab published a research article in ACS Nano.