The ability of immune cells - such as macrophages - to internalize particles by phagocytosis is central to the defense against pathogens.
Macrophages and dendritic cells of the innate immune response process antigens into structures that are recognized by T cells of the adaptive immune response. At M&I, this area of research involves many of us.
We use quantitative fluorometric and microscopic methods to delineate the mechanisms and regulation of phagocytosis.
Within this field, we are studying several areas:
- The mechanisms involved in antigen uptake and presentation to T cells, along with studies of how pathogens interfere with these processes
- The innate immune responses to specific bacterial, viral, fungal and parasitic pathogens
- Macrophages that can sense bacterial molecules within the cytosol, which triggers expression of various cytokines, and other pro-inflammatory genes. We are seeking to identify signaling molecules and transcriptional regulators that are specific to this cytosolic surveillance pathway, using the Gram-positive intracytosolic bacterium, Listeria monocytogenes as a model pathogen.
- The effects of innate immunity on pathogenesis of Vaccinia virus and in particular the mechanisms through which interferons and toll-like receptor signaling pathways affect vaccinia viral replication and spread in the lung. We are focusing on understanding the cellular and molecular effectors involved in the initiation of immunity to model fungal pathogens such as Cryptococcus neoformans.
Professor
Professor of Internal Medicine
Professor of Microbiology and Immunology
Associate Dean for Physician Scientist Education and Training
Professor of Microbiology and Immunology
Associate Dean for Physician Scientist Education and Training
Leland Ira Doan Research Professor of Vascular Surgery
Associate Chair, Department of Vascular Surgery Section
Professor of Surgery
Professor of Microbiology and Immunology
Associate Chair, Department of Vascular Surgery Section
Professor of Surgery
Professor of Microbiology and Immunology
Center Member
Nina and Jerry D Luptak Research Professor
Research Professor
Mary H Weiser Food Allergy Center
Professor of Internal Medicine
Professor of Microbiology and Immunology
Professor of Molecular, Cellular and Developmental Biology
College of Literature, Science, and the Arts
Research Professor
Mary H Weiser Food Allergy Center
Professor of Internal Medicine
Professor of Microbiology and Immunology
Professor of Molecular, Cellular and Developmental Biology
College of Literature, Science, and the Arts
Program Director, Microbiology and Immunology DEI Initiatives
Associate Professor of Microbiology and Immunology
Associate Professor of Microbiology and Immunology
Nancy Walls Professor of Microbiology and Immunology
Chair, Department of Microbiology and Immunology
Professor of Microbiology and Immunology and Professor of Internal Medicine
Chair, Department of Microbiology and Immunology
Professor of Microbiology and Immunology and Professor of Internal Medicine
Assistant Professor of Microbiology and Immunology
Frederick C Neidhardt Collegiate Professor
Professor of Microbiology and Immunology
PhD Program Director & Graduate Studies Chair
Microbiology & Immunology
Professor of Microbiology and Immunology
PhD Program Director & Graduate Studies Chair
Microbiology & Immunology
Professor of Internal Medicine
Professor of Microbiology and Immunology
Professor of Microbiology and Immunology
Nancy Walls Research Professor of Microbiology and Immunology
Professor of Microbiology and Immunology
Professor of Microbiology and Immunology
Professor Emeritus of Microbiology and Immunology
Assistant Professor of Microbiology and Immunology
