Our Skin Aging and Photobiology research group is investigating the mechanisms that underlie age-related degradation of the dermal extracellular matrix (ECM) and how age-related changes to the dermal ECM contribute to skin fragility, weakened immunity and skin cancer.
We have characterized age-related structural and functional changes within the dermal ECM using molecular biology, biochemistry, and advanced imaging techniques. This work supplied foundational knowledge that helps guide our ongoing investigation of the molecular basis of connective tissue aging and its role in the biology of aging.
Focused on age-related changes impacting the dermal ECM, our studies seek to identify novel targets for future therapies to improve skin health in the elderly.
Ongoing studies utilize novel murine models of accelerated dermal aging to investigate the roles of matrix metalloproteinases and matricellular proteins in dermal aging and the connections between skin aging, systemic aging, and skin cancer.
We are investigating the role of the YAP/TAZ signaling pathway in regulating both dermal fibroblast adaptation and age-related dermal extracellular matrix homeostasis.
We are studying how elevated expression of CCN1 in aged human skin alters the extracellular matrix and thereby contributes to a dermal microenvironment that enhances initiation of keratinocyte cancer.
Our translational studies examine how injectable dermal fillers, such as cross-linked hyaluronic acid, stimulate regenerative responses within dermal fibroblasts and the dermal extracellular microenvironment, and how these processes may lead to clinical improvement.
Professor of Dermatology
Dermatology
Associate Chair, Department of Dermatology
Clinical Associate Professor of Dermatology
Scientific Trunk Director
Assistant Program Director of Residency Curriculum
View publications from Gary J. Fisher, PhD.
